EMS and law enforcement agencies responded to an accident four miles outside of Ashburn along Highway 112 shortly after six o'clock Wednesday morning.
Georgia State Patrol troopers confirm that 72-year-old Dorothy Blanton was returning to a nearby residence on Highway 112 when she turned off a dirt road near the golf course, crossing into the westbound lane.
While in the westbound lane her car was struck head-on by a tractor trailer; the impact killed her instantly.
Blanton is a nurse at Tift Regional Medical Center.
Officials say that Highway 112 was closed for approximately three hours but is now re-opened to motorists.